"The narcotics kingpin is expected to be sent to a high-security Colorado prison dubbed the 'Alcatraz of the Rockies" about 90 miles south of Denver in the USA.
ADX has special restrictions in place created to ensure some inmates have no way to project influence beyond prison walls.
With Guzman convicted of drug trafficking and facing an expected life sentence, where will the USA imprison a larger-than-life kingpin with a Houdini-like tendency to slip away?
Guzman escaped from Mexican prisons twice - once in 2001 by hiding in a laundry bin and again in 2015 through a mile-long tunnel that had been dug beneath the shower in his jail cell.
But the criminal mastermind who committed murder, money laundering and weapon offences throughout his decades-long reign could finally be retired for good.
'I think he was convicted even before he came to America, ' Lichtman said.
Within months of his arrest, Mexican authorities extradited Guzman to NY to face charges.
He added: "The prisoners really have no contact with other prisoners, all their movements are controlled. It's a tough place to do time". One former prisoner, in an interview with The Boston Globe, described the lockup as a "high-tech version of hell, created to shut down all sensory perception".
One unnamed ex-prisoner, 36, who spent six years at Supermax between 2008 and 2014 for his role in prison riots at two federal jails, told Reuters conditions were nearly "inhumane".
Guzman's lawyers did not deny his crimes as much as argue he was a fall guy for government witnesses who were more evil than he was.
After escaping imprisonment on two previous occasion, he was finally captured in a shoot-out in January 2016 and extradited to the US.
When asked why he decided against putting Guzman on the witness stand, Lichtman explained that it was rear in a criminal trial, and that he deemed it a losing strategy, considering the amount of evidence the prosecution could have cross-examined him on.
But Guzman, due to be sentenced in June for smuggling enormous amounts of narcotics into the USA and having a hand in dozens of murders, would stand out even from this infamous roster because of his nearly mythical reputation for breaking out.