Five unnamed friends of the duchess spoke to People in an effort to counter the "global bullying" directed at her.
"Just seeing them broadcast a letter from a daughter to a father, she's getting a raw deal there and I think it's irresponsible and I'm surprised by that", Clooney added.
"She told them both that the whole thing was becoming a nightmare, and that they should try and sort things out", claimed the friend.
"Meg has silently sat back and endured the lies and untruths", one former co-star said.
She wrote: "I have only ever loved, protected and defended you, offered whatever financial support I could, anxious about your health...and always asking how I could help".
You've told the press that you called me to say you weren't coming to the wedding - that didn't happen because you never called.
While she recognises that the internet has been good in many ways, enabling people to communicate all over the world and allowing her to promote her charitable causes, Sarah Ferguson, 59, admitted that a lot of the websites "terrify" her. "They are the ones who see best the effect that the mistruths and the rumours are having on her", she asserted. She further revealed how by doing so it will "open the floodgates" for "bad publicity". "You sent me an email last October that said: 'If I've depended too much on you for financial help then I'm sorry but please if you could help me more not as a bargaining chip for my loyalty".
"They're just chasing Meghan Markle everywhere, she's been pursued and vilified", Clooney told Australian magazine WHO.
Meghan's messages to the vulnerable women during her visit on February 1 read, in capital letters and often followed by a heart: "You are strong", "You are special", "You are brave" and "You are loved".
She goes on to complain that Mr Markle has made no attempt to contact her - and chastises him for falsely telling journalists he is the one who has been shunned - a criticism her father refutes.