A furious Trump responded by questioning whether the author even existed, and said that if the person does exist, the writer is "gutless" and must be outed for national security purposes. Melania concluded by saying, "To the writer of the oped, you are not protecting this country, you are sabotaging it with your cowardly actions".
But the speculation over the author's identity was not limited to the White House - much of Washington was also buzzing with rumours and speculation.
US President Donald Trump is still furious over the anonymous op-ed.
The piece says administration officials have discussed the possible use of the 25th Amendment.
Through his spokesperson, Pence denied he was the White House insider dishing the dirt on President Trump. "And this person chose instead, according to the New York Times, chose not only to stay, [but] to undermine what President Trump and this administration are trying to do".
Mr Trump described the writer as "gutless" and the newspaper as "phony".
A spokesman for Pence criticised the Times and said the vice president does not write anonymous opinion columns.
"But it didn't accomplish anything, because Trump's base could care less, the president could care less".
He also attributed the op-ed to the "deep state", writing on Twitter, "The Deep State and the Left, and their vehicle, the Fake News Media, are going insane - & they don't know what to do".
It is sad more than anything else that the United States has come to where you have again. if it is what it's purported to be, it is sad that you have someone who would make that choice, he said.
The author also denounced in the piece the president's "amorality" and described his impulses as "generally anti-trade and anti-democratic" and his leadership style as "impetuous, adversarial, petty and ineffective".
The author is believed to be a senior White House official.
As Yashar Ali of New York Magazine noted, Trump officials have been known to purposely copy language of other senior staffers when leaking news in an effort to throw the paranoid president off their trail.