Gérard Depardieu is the latest famous star facing sexual assault allegations.
"The Paris public prosecutor's office is making a preliminary investigation on counts of rape and sexual assault", the spokesman said.
He was also nominated for a best actor Oscar in 1991 for his role in Cyrano de Bergerac.
Fallen movie mogul Harvey Weinstein is now under investigation in London, New York, and Los Angeles following a string of sexual assault allegations.
The allegations against the 69-year-old were formally made to police by a 22-year-old French actress on Monday, French radio reports.
The woman reported the alleged incidents to police in Provence who... He has agreed to cooperate with the investigation, according to his lawyer.
"I regret the public nature of this process which poses a major prejudice to Gerard Depardieu, whose innocence I am convinced will be recognized", Termine added.
Once described by actress Brigitte Fossey as "both an ogre and a poet", Depardieu worked under directors ranging from Bernardo Bertolucci, Andrzej Wajda, Jean-Luc Godard and Ridley Scott.
Depardieu stars in Netflix's French series "Marseille". He rose to global fame when he bagged a Golden Globe for his 1990 role as Georges in the romantic comedy Green Card.