It is unclear on how Boyle's departure will affect the movie's US theatrical release of November 8, 2019.
Oscar-winning British film director Danny Boyle has exited the 25th James Bond movie over "creative differences", the official 007 website announced on Tuesday.
It was confirmed in May that the Trainspotting and Slumdog Millionaire filmmaker was due to direct the 25th Bond film.
It will be Craig's fifth appearance as Bond and when it was announced Boyle would come on board in May, production chiefs said they were "delighted".
It was announced by producers Michael G Wilson and Barbara Broccoli, and current Bond star Daniel Craig. He had always been in MGM and Eon's sights to board a James Bond movie, dating back to 2012's "Skyfall" and 2015's "Spectre". However, it seems "creative differences" have gotten in the way.
Danny Boyle's tenure as a Bond director ended up being short-lived.
No replacement director has been named at this time. MGM and EON Productions plan to release it in the United States on November 8, 2019.