Iniesta's last involvement with the Spanish side came today in the side's disappointing performance against World Cup hosts Russian Federation, where Spain went out via a penalty shootout in the round of 16.
Spain didn't do enough as they searched for a victor in both regulation time and the additional 30 minutes, with Russia's defenders keeping their concentration throughout. "He went out as if it were his first game as a professional, helping his team mates". "He is one of the best players in Spanish football history - I can't say anything else".
The 32-year-old Spaniard - who won the World Cup in 2010 - posted on social media late on Sunday night.
Spain became the first team since at least 1966 to make over 1,000 passes in a World Cup game, but created very few clear chances over the 120 minutes.
Russian Federation equalized before halftime when Spanish defender Gerard Pique gave away a penalty via a handball in the box.
"This was my last game for Spain", Iniesta told reporters.
England know their opponents in the last-16 after Colombia topped Group H. The South Americans reached the quarter-finals last time out and are clearly stronger than Japan, who came second in the group. "On a personal level, it's the end of a wonderful phase".
Sweden and Switzerland have both performed admirably at the World Cup but neither should strike fear into English hearts.
Tens of thousands of fans in the capital's Federation Internationale de Football Association fan fest crowded around several huge screens as they witnessed what many of them would have believed unthinkable before the match.
A Russian fan celebrates his team's win over Spain in the World Cup.
"This morning I was very nervous, but now it is time to celebrate".