The charges stem from encounters with two of the dozens of women - some famous, some not - who have accused him of sexual misdeeds.
Here are the key developments in his downfall.
In a statement to Mic, organizers of the Women's March called Friday "an important day in terms of visibility for all women whose lives have been devastated because of the actions of Harvey Weinstein", adding, "We seek justice for women and all people who have been harassed and abused in the workplace".
Weinstein was a fixture in elite entertainment circles in Manhattan and Los Angeles until his accusers came forward. Asia Argento, who has also accused Weinstein of rape, tweeted a live feed of Weinstein's "perp walk" on Friday morning.
Weinstein has denied having non-consensual sex with anyone, and his lawyer Benjamin Brafman said he meant to plead not guilty.
Harvey has two children with his ex-wife Georgina Chapman and three children from his first wife Eve Chilton Weinstein. At the time, Evans was a college student with hopes of becoming an actress. "We believe that they are not factually supported by the evidence".
Officers in the United Kingdom have received 15 separate allegations of sexual assault on dates ranging from the 1980s up until three years ago.
In 2017, he was expelled from the Academy of Motion Picture Arts and Sciences after racking up Oscars for a string of films that helped define independent cinema in the 1990s, including "The Crying Game", "Shakespeare in Love" and "Pulp Fiction". The other says Weinstein allegedly raped her in 2013.
Weinstein sues his former studio to gain access to his emails that he believes contain information "exonerating" him from claims of sexual harassment and assault.
Earlier this year, it was reported that the allegations against Weinstein now date back to the 1970s.
Weinstein, 66, stepped from a black SUV and walked slowly into a Manhattan police station before a crowd of news cameras.
"We intend to move very quickly to dismiss these charges", Mr Brafman said.
He appeared in court later and was charged with assaulting Lucia Evans, who told investigators he forced her to perform oral sex on him in 2004.
Rose McGowan, one of Weinstein's most outspoken accusers, told The Hollywood Reporter Friday's arrest brings victims "one step closer to justice". He tried to usher her into his room but she protested, asking him: "Why yesterday you touch my breast?"
Mr Weinstein has continuously denied non-consensual sex and this would be the first time he has been charged.
The majority of stars wear black in solidarity with victims of sexual assault, while numerous speeches and commentary at the event are geared towards the events of the past few months.
"I said, over and over, 'I don't want to do this, stop, don't, '" she told the magazine.
During a brief court appearance, during which Mr Weinstein did not speak, prosecutor Joan Illuzzi said the former mogul had "used his position, money and power to lure young women into situations where he was able to violate them sexually".
Weinstein's career went down in flames in October over sexual assault allegations following bombshell articles in The New York Times and New Yorker, which sparked a sexual harassment watershed across the United States.
She also recalls a second incident in which it is alleged he threatened to derail her career.
His arrest came months after Vance's office reportedly launched an investigation into allegations of sexual assault. If it takes this one case to get him in jail, then so be it. "I would say it's just so big".
British police receive a further allegation of sexual assault, bringing the total number of women who have reported the disgraced movie mogul to police in the United Kingdom to 10. His lawyer, Benjamin Brafman, didn't elaborate further on the denials on Friday (Saturday NZT), saying he wasn't there "to try the case" at this point.
The news that Weinstein was planning to surrender to NY authorities broke earlier this week.
Carrying books, Harvey Weinstein arrives at the first precinct in New York CIty while turning himself in to authorities.
There he confirms he understands the charges and agrees to conditions for his release.
Bail was set at $1 million and Weinstein was fitted for an electronic monitoring device.
One of the cases was in NY, where Italian model Ambra Battilana accused Mr Weinstein of groping her in 2015.