At the back, Phil Jones and Marcos Rojo have been ruled out of the match.
Ander Herrera, Phil Jones, Marcus Rashford, Antonio Valencia, Marcos Rojo, Marouane Fellaini and Zlatan Ibrahimovic all missed out due to injury, while Paul Pogba was sidelined by illness against Huddersfield in the FA Cup.
"He's the same as any other player and Mourinho has come out very strongly in a statement that's really said "I'm in control" and it's about controlling players, not about keeping them happy".
"Can we recover some of them to Wednesday?" Paul (Pogba), I don't know. I don't think they have any chance.
"So we arrive at this crucial moment with some problems, but I think mentality is very important". We have strong team ethics, strong team mentality. "We know it is a very hard match but we go for it", concluded the 55-year-old.
The two sides meet in the first leg of their tie at the Ramon Sanchez Pizjuan on Wednesday, with United the favourites to advance to the quarter-finals having won their group.
"It was hard for us, Brighton".
Meanwhile, Spanish news outlet Sport has reported that the reigning La Liga champions are not really interested in signing Pogba because they do not need to strengthen their midfield since they already have quality players like Luka Modrić, Tono Kroos, Isco, and Marco Asensio in the squad.
"Every day you deal with at least 11 unhappy players who haven't played on the Saturday, three players who have been brought off are unhappy, three players going on are unhappy because they should have gone on earlier".
"United fans will be relieved to hear that Mino Raiola isn't the most popular man at the Bernabeu, and club president Florentino Perez has never bought a player from the super agent".
Pogba hasn't completed 90 minutes in a month as he has been hauled off by Jose Mourinho in defeats at Tottenham and Newcastle, and dropped by the Portuguese for victory over Huddersfield at Old Trafford in between.