Syrian forces are poised to enter two contested enclaves, Afrin - where Kurdish militiamen are battling the Turkish army and its Syrian surrogates - and Eastern Ghouta, next to Damascus, where jihadis continue to fight the army.
According to the Britain-based Syrian Observatory for Human Rights said, "Amongst the 77 people who have been killed, at least 20 children have been killed in this assault".
"14 people were killed in ground and air attacks in the town of Saqba, while four others were killed by an airstrike in the town of Jisrin", the statement added.
"We in Ghouta have been getting hit by airstrikes for more than 5 years and this is not new to us. but we have never seen anything like this escalation".
There are nearly 400,000 people in Eastern Ghouta, the largest opposition stronghold left near the capital, according to the UN.
But time appeared to be running out for an agreement Sunday and regime forces, who have been receiving aerial backing from Russian Federation, looked on the brink of starting a major offensive.
How bad is the situation in Eastern Ghouta?
Syria has been embroiled in a civil war since 2011.
Despite the agreement, almost 200 people were killed in Eastern Ghouta and in Idlib within a four-day period earlier this month. They said that events in their suburb are playing out similarly to the 2016 offensive in Aleppo, when rebels and ISIS militants were expelled by a government offensive that reduced much of the city to rubble.
"UNICEF is issuing this blank statement". United Nations officials say malnutrition is rife, although Eastern Ghouta was once the capital's market garden. I find it cruel and sickening that aid has not been allowed into Ghouta for months while the city has been relentlessly attacked.