Our answer? No. It's not fair that we have so much wealth when billions of others have so little.
When asked if the national reckoning over sexual harassment had affected her investments through Pivotal, Melinda Gates said that it hadn't so far, but that it had encouraged her to use her voice to encourage more women to speak out.
"The "America First" world view concerns me", Mr Gates said.
Is it fair that you have so much influence?
Distributed by African Media Agency (AMA) on behalf of The Bill & Melinda Gates Foundation. Melinda believes it would be hard to argue "we made the world focus too much on health, education, or poverty".
Melinda Gates tore into President TrumpDonald John TrumpTillerson: Russia already looking to interfere in 2018 midterms Dems pick up deep-red legislative seat in Missouri Speier on Trump's desire for military parade: "We have a Napoleon in the making" MORE's proposed budget, warning against cutting funds for programs that help women and children.
On the question of philanthropy at home, the Gateses acknowledge that the $500million they spend in the United States each year - mostly on education - pales compared to the $4billion the foundation spends in developing countries.
"For decades the United States has been a leader in the fight against disease and poverty overseas", he said. Now, instead of imposing certain approaches, the foundation is working with schools to develop local strategies to help students succeed.
This question is likely to strike a chord with a number of those in the startup space, as a regular ongoing conversation - and sometimes a point of contention - is the extent to which startups should work with corporate partners. The answer may seem counterintuitive, she wrote, but the evidence is clear in historical birth trends from around the world.
"The headlines are filled with very bad news", they write in the letter.
And while the Microsoft co-founder loves to tuck into a good book about social progress (or five), he's also mindful of the criticism or scepticism sometimes directed at the massively wealthy foundation headed up by he and his wife. Where we go, who we spend our time with, what we read and watch and listen to - these decisions are made through the prism of our work at the foundation (when we're not watching "The Crown" or "The Man in the High Castle.").Maybe 20 years ago we could have made a different choice about what to do with our wealth.
Melinda Gates responded that "it's not fair" that their "wealth opens doors" and "world leaders tend to take [their]... phone calls", but added that the Gates Foundation is "committed" to maintaining transparency.
Attributing most of it to their upbringing, both aimed at nurturing what their parents had sowed in them.
Though Gates admitted that we "disagree with this administration more than the others we've met with", he reiterated the need to "work together whenever possible".