Netanyahu's remarks came as he convened his security chiefs for consultations on Saturday's confrontations which followed Israel's interception of what it said was an Iranian drone launched from Syria.
"What we're watching is an attempt by the Iranians to shape the situation in Syria as we approach the end of the civil war in a way that serves Iranian interests", said Yossi Kuperwasser, former director general of Israel's Strategic Affairs Ministry and now a senior fellow at the Jerusalem Center for Public Affairs. Israel responded with a "large scale attack" on 12 bases in Syria.
Danny Danon, Israel's ambassador to the UN, speaks at the General Assembly, December 21, 2017, at United Nations headquarters. An Israeli F-16 was subsequently shot down.
Iran, Israel's regional arch-enemy, rejected as "ridiculous" reports that Israel had intercepted an Iranian drone launched from Syria on Saturday, state TV reported.
Conricus said the army had confirmed "accurate hits of (the) Iranian UAV control facility" in Syria.
"The government and army of Syria as an independent country have a legitimate right to defend (the country's) territorial integrity and counter any type of foreign aggression". State Department spokeswoman Heather Nauert, commenting on Israeli military action in Syria, stressed that the United States "strongly supports" Israel's right to defend itself.
She said Washington continues to push back on the totality of Iran's "malign" activities in the region and called for an end to Iranian behavior that "threatens" peace and stability.
Meanwhile, Russia's Foreign Ministry said that "the latest developments and attacks on Syria were viewed with serious concern" and that the loss to Syria and damage resulting from them were being examined. "We do not confirm any such news from Israel", he said. "We will continue to do whatever is necessary to protect our sovereignty and our security". Iran has considerably increased its presence in Syria since the outbreak of that country's civil war in 2011.
Giving more details on how events unfolded, the IDF's Conricus told CNN an Iranian unmanned drone had been dispatched on a specific mission inside Israel.
"Twelve targets, including three aerial defence batteries and four Iranian targets that are part of Iran's military establishment in Syria were attacked". "The risk is a direct confrontation between Israel and Iran that will encompass Syria and Lebanon".
Israeli aircraft have been operating relatively freely in Syria and Lebanon since the 1980s despite encountering largely ineffective anti-aircraft fire.
But yesterday, after the downing of the F-16, an official in the pro-Assad alliance said a "message" had been delivered to Israel. "We are willing, prepared, and capable to exact a heavy price on anyone that attacks us".
"We won't accept either of those, and will act according to our needs", Netanyahu said following the meeting with Putin.
"Iran seeks to use Syrian territory to attack Israel for its professed goal of destroying Israel".
The regime said it intercepted the missiles and destroyed a lot of them, according to SANA.