52 people were burnt alive when a bus burst into flames.
Only five people were evacuated in time from the blazing bus.
It said that 55 passengers and two drivers were aboard the vehicle, but that only five of them managed to survive. Rescue personnel saved five people from the burning vehicle and provided medical assistance, authorities said.
Ministry representative Imankulov did not confirm this however, telling AFP: 'It's too early to talk about the reasons for the fire'.
Kenes said the "preliminary theory" of investigators about the cause of the fire was a "short circuit".
All the victims are believed to be Uzbek migrant workers on their way to the city of Kazan in Russian Federation, a Kazakh emergency ministry official told ABC News.
The bus is thought to have been carrying Uzbek citizens to or from Russian Federation along the Samara-Shymkent route.
Flames spread "extremely quickly" through the bus, which was carrying passangers from neighbouring Uzbekistan, Ruslan Imankulov, an emergency services ministry official, said.
The nationalities of the passengers and the cause of the accident is unknown.