Professor Allan Pacey from the University of Sheffield, cautions: "The results suggest that long-term use (several weeks) of ibuprofen can affect the production of the male hormone by the testicles".
The team of investigators from Denmark, France and China found that within two week these men had an elevated risk of compensated hypogonadism, "a condition prevalent among elderly men and associated with reproductive and physical disorders", researchers note. But there were indications that something was off. Tissue in the male brain senses the level of testosterone and, if it's too low, produces luteinizing hormone, which stimulates the testes to make more. Of course, there is a bright side to this new finding, and that is to limit your intake of ibuprofen.
In addition to limiting fertility, ibuprofen or NSAIDS, may increase the risk of heart attack or stroke.
Half the group took 600mg of ibuprofen twice a day - the maximum recommended dose in the U.S.is 800mg up to four times a day - for 2 weeks.
All 3 drugs are considered anti-androgenic, meaning they disrupt male hormones..
The adverse effects in the study weren't permanent. The higher and longer the level of exposure, the researchers found, the more dramatic the impact.
On its own, a study this small would be little more than a call to do more detailed studies.
Oh no! A new study shows that ibuprofen can have a negative effect on male fertility! So not only is the shrinking of your balls concerning on a personal level, it could also suggest you're going to die earlier.
According to the Proceedings of the National Academy of Sciences, prolonged and heavy use of the drug "alters human testicular physiology to produce a state of compensated hypogonadism".
If you are concerned about your levels of testosterone and your ibuprofen use, though, it's worth chatting to your GP so you can get checked out and find a way to deal with chronic aches and pains in a healthy way.