Manchester City saw their record 18-game winning run in the Premier League ended with a 0-0 draw at Crystal Palace on Sunday, with the leaders dealt a further blow with injuries to Gabriel Jesus and Kevin De Bruyne.
But the opening relentless tempo was momentarily quashed as Scott Dann was stretchered off after what looked like a serious collision of knees with City attacker Kevin De Bruyne as the 26-year-old skipped past the Liverpudlian on the edge of the area.
"We will recover one or two players who were unable to play today before the Southampton game, but after an effort like this you'd wish we could make the amount of changes that Manchester City feel they can always make when you look at the quality of the players they have who aren't playing".
Guardiola's team have already passed many tests this season, but it is now that their endurance will be questioned.
Manchester City now sit 14 points clear at the top of the league. We knew that. The second half was better than the first.
"Maybe [it was penalty] - I didn't see it really well", he sad.
But the previously sensational Belgian's set-pieces were off colour - only one of six deliveries was risky, and his passing accuracy (80%) was less than any other starting City player.
"I'm very proud of the team's performance", said Hodgson.
Asked whether City will make a move when the transfer window reopens on January 1, Guardiola said: "I don't know".
The injury to Jesus could prompt City to bring forward plans to sign Alexis Sanchez from Arsenal, with the current necessity for firepower likely to outweigh the determination to wait until the summer to sign the Chilean on a free transfer. "In two days we have another game after that we have meetings".
"But my feeling now is Alexis is an Arsenal player".
Hodgson claimed before the game there was "no magic formula" to competing with City, insisting his Palace side's hopes of getting something from the game hinged on working hard, and defending well while maintaining an attacking threat.
Wayne Hennessey was the first Crystal Palace goalkeeper since Nigel Martyn in May 1993 to keep a Premier League clean sheet against Man City.
City leads the Premier League by 14 points after 21 of 38 rounds.
It is all "ifs" right now, but the chasing pack did not even have those to cling to before the Crystal Palace game.