Officials say late January and early February form the peak of flu season.
The Alabama Department of Public Health (ADPH) on Friday issued an alert of increased influenza (flu) activity across the state.
Symptoms of the flu include fever, cough, sore throat, runny or stuffy nose, muscle or body aches, headaches and fatigue.
"They're seeing that it's anywhere from 10 percent to 33 percent effective, so any time there's a mismatch between the vaccine and the circulating strain of the flu, you're going to see more cases".
North Carolina officials have reported the state's first child death from flu for this season.
Achebe said not everyone who gets the flu is asked whether they were immunized, but a few people who got the shot still got sick.
"While flu vaccination is still recommended for people who have not yet gotten vaccinated, antiviral drugs are an important second line of defense that can be used to treat flu illness", the USA agency added.
The flu season shows no sign of slowing down with 478 confirmed cases in Central Alberta and 49 people ending up in hospital.
In addition to the child, 11 adult flu-related deaths have been reported in North Carolina this season, which began October 1.
Nationwide, nine children have died because of the flu through December 16.
Decatur Memorial Hospital is encouraging people to follow three steps to prevent infection: clean their hands, cover their mouth and nose and avoid close contact with others if they become sick. Last week, the death toll from the flu outbreak in the county reached 11.
Health experts recommend that vulnerable populations especially, including children, pregnant women, older residents and people with medical complications, get vaccinated.
H3N2 "tends to be the strain of virus that most impacts the elderly, that causes the most complications, and up until this point the vaccine results have been quite disappointing", said Dr.