Jones was 34-27 at Tennessee, including back-to-back nine-win seasons in 2015 and 2016. Fox Sports' Bruce Feldman was the first to report the news late Sunday morning.
But losing to Missouri in Columbia, a team that Tennessee defeated 63-37 last season, was all athletic director John Currie could stand and everyone involved with the Vols football program could stand no more.
The move comes after Tennessee's 50-17 loss to Mizzou on Saturday night.
"We have been fortunate to have coach Jones lead our program for the past five years", Currie said.
The Volunteers are 0-6 in the Southeastern Conference this season with a 4-6 overall record.
The Vols lost to LSU in that season's SEC Championship and beat Wisconsin in the Outback Bowl.
Unfortunately for Jones, his time at Tennessee was also marred by an array of bad losses, including a 24-21 defeat at the hands of SC in 2016 and a 45-34 loss to Vanderbilt later that season. With Tennessee looking for a new coach the five most popular names to become the next Vols head coach are below.
Jones took over Tennessee in 2013 as Derek Dooley's replacement. They have also lost their last game against each of the other 13 teams in the SEC dating back to 2011.
Regardless of preseason projections, a 4-6 overall record and 0-6 mark in the SEC was not what anyone wanted to see in Knoxville. I want to make clear that we are intensely committed to hiring the best coach of Tennessee.
Defensive line assistant Brady Hoke will assume the interim head coach responsibilities for the Vols. Now Tennessee can officially join rival Florida on the coaching carousel in the pursuit of its next coach. He can certainly provide a steadying hand, drawing on previous head coaching experience at Ball State, San Diego State and MI. Ever since back-to-back home losses to Georgia and SC earlier this season, it has seemed likely that Tennessee would move in a different direction at the end of the year.
The 59-year-old Hoke has head coaching experience at Ball State (six years), San Diego State (two years) and MI (four years), and after his dismissal at MI after the 2014 season, Hoke was out of coaching for a year before spending the 2016 season as Oregon's defensive coordinator.