Kane has been in red-hot form leading the top scorer chart for Premier League this season, scoring eight in the Premier League and 13 in all competitions.
Former Manchester United hero Ryan Giggs has claimed that the Red Devils need a win against Tottenham more than the London club does. "But tomorrow, it is impossible". "It's lucky it's not a big problem but he's not going to play tomorrow", Pochettino added.
Kane has been a regular starter for Spurs this season, both domestically and in Europe, only missing a couple of matches including the 3-2 loss to West Ham in midweek. "I think Jose Mourinho and the fans would take that and forget about producing an entertaining performance".
And Manchester United legend Rio Ferdinand believes Spurs have no chance of beating United without Kane.
Kane is the most expensive player in the official game, so subbing him out will give managers plenty of cash to play with as they hunt for replacements.
And not only did Mauricio Pochettino's team avoid defeat in that time, they won five of those - including one against current league leaders, Manchester City.
Third-placed Tottenham, who thumped Liverpool 4-1 at Wembley last weekend, are level on 20 points with second-placed United after nine games.