He was the youngest ever victor of the Perrier award in 1990 with his show A One Night Stand With Sean Hughes.
His most recent tweet, published on October 8read simply: "In hospital".
Matt continued: 'He'd been unwell, but when I started out on the comedy circuit about 25 years ago, Sean was one of the biggest stars'.
In a 2014 interview with the Irish Times, Hughes joked about his life of "extreme" hedonism.
According to reports, Hughes' death was caused by liver cirrhosis, a condition caused by long-term liver damage.
Comics including Sarah Millican, Julian Clary, Jack Dee, Al Murray and Leigh Francis all took to Twitter to pay their respects, with many sharing memories of working with him.
Des Bishop wrote, "Sad to hear about Sean Hughes". A brilliant comic and a lovely bloke.
Irish comedian Aisling Bea tweeted, "So sad".
"I am a huge fan of his and am very sad to hear this news".
Aside from comedy, Hughes was also known for his film roles, starring as a record producer in cult film "The Commitments", as well as appearing as the lead star in the 2002 movie "Puckoon". That's no age. One of the Irish comedy trailblazers in the United Kingdom'.
Away from the stage and screen Hughes was also a writer, penning best-selling novels The Detainees and It's What He Would Have Wanted.
Sean leaves behind his mum and two brothers.