Beckham Jr. clearly had tears in his eyes while being taken off the field, signaling the possible severity of this injury.
The next play, Manning was sacked and fumbled, which the Chargers recovered at the Giants' 11-yard line.
New York Giants (0-5) receiver Odell Beckham Jr.is "headed for surgery", according to ESPN's Jordan Raanan. The 0-5 Giants could be in a position to target Eli Manning's successor in the 2018 draft if they continue on this bad trend.
As for the rest of the game, the Giants blew three leads, including two in the second half.
Beckham's ankle was trapped under a Chargers defender he crumbled to the ground.
Marshall attempted to make a catch deep down the right sideline and hurt his left leg when he came down awkwardly out of bounds.