While Ajayi didn't look bad, the Dolphins' offense as a whole struggled, leaving the running back with limited opportunities. And all this on what was meant to be a glorious homecoming for the man who was born just 12 miles from Wembley.
Despite nursing a knee injury in the run-up to Sunday's game, Ajayi made his global series bow debut after missing out on the Dolphins' defeat to the Jets two years ago with a cracked rib.
Ajayi, who moved to the United States at age seven, also shared a special moment with his childhood hero as he hugged retired footballer Thierry Henry before the game.
Do the Dolphins have the worst offense in the NFL?
Dolphins coach Adam Gase labeled his offense "trash" following last week's 20-6 loss to the Jets.
Ajayi said: "It's extremely frustrating".
"We need to have some pride in ourselves and have some respect for ourselves and put some points on the board". An appearance launching a lifestyle brand in Soho drew huge crowds and he was extremely popular at the National Football League event on Regent Street Saturday.
Brees threw for 268 yards and two touchdowns and the Saints scored all but three of their points in the second half as they defeated the Miami Dolphins 20-0 on a rainy Sunday afternoon at Wembley Stadium. I got to see my family, but this game was the main objective of the trip.
Before last week's game, 10 Saints-including Adrian Peterson-sat on the bench.
"Obviously those first two weeks weren't what we aspired to be, we played two real good teams, the Vikings and Patriots", Brees said. "I felt we had a great plan coming out here, obviously it's a tough trip coming across the pond". This was our next game, our next opportunity to get a win, whether it was in London or Miami.
"Everyone needs to be held accountable on our offence because we're not doing what we need to do and we need to figure it out". People are tuning in now to see what we're going to do and not watch the game.