The jury awarded the woman $70 million in damages and an extra $347 million in punitive damages. She added, "We are preparing for additional trials in the USA and we will continue to defend the safety of Johnson's Baby Powder".
The company argued that federal agencies like the Food and Drug Administration have not ruled talc to be carcinogenic.
There are about 4,800 similar claims nationally, including four lawsuits in Missouri where Johnson & Johnson dished out more than $300 million total in damages.
Johnson & Johnson said in an emailed statement to Becker's Hospital Review the company plans to appeal following the jury's verdict.
63 year old Eva Echeverria said she began using the powder when she was 11.
The first talcum powder lawsuit in California came to a close with a thunderous $417 million verdict against Johnson & Johnson on Monday August 21, 2017.
Johnson & Johnson baby powder has been linked to ovarian cancer.
The American Cancer Society notes several studies have suggested "a very slight increase" in risk of ovarian cancer for women who use talc-based powders for personal hygiene.
"We are grateful for the jury's verdict on this matter and that Eva Echeverria was able to have her day in court", one of the plaintiffs' lawyers said yesterday after the verdict was read in Los Angeles Superior Court.
J&J has latched on to a U.S. Supreme Court ruling in June limiting where cases can be filed in an effort by the company to shed other pending talc cases. To win the case, Echeverria had to establish both general causation-that talc can cause ovarian cancer-and that talc exposure was "a substantial factor" in her contracting the disease.
Two similar cases in New Jersey were thrown out by a judge based on a lack of reliable evidence linking talc to ovarian cancer. Mrs. Echeverria never wanted any sympathy but just wanted to spread the message to help her fellow suffers. She also blamed the company's talcum powder for the illness, which she had been using for 40 years.
The jury found that the company failed to warn the woman about the increased risk of ovarian cancer caused by talcum-based powders, Reuters reports.
"We are preparing for additional trials in the USA and we will continue to defend the safety of Johnson's Baby Powder", she added.
The company lost three other similar trials in Missouri past year, which it paid out a total of more than $300 million in damages for.