Chelsea are starting with new signing Alvaro Morata on the bench with Michy Batshuayi being favoured in attack.
Another player who will feature against Chelsea is Laurent Koscielny.
Arsenal's club-record £46.5m signing Alexandre Lacazette and new defensive arrival Sead Kolasinac are in line to feature, but Francis Coquelin (ankle), Gabriel (knee) and Jack Wilshere (leg) will miss out because of injury.
In the past Wenger has been powerless to turn down City's millions for the likes of Emmanuel Adebayor, Samir Nasri and Kolo Toure as Arsenal were paying off the building costs of the Emirates Stadium. It is expected that Shkodran Mustafi who took part in Germany's Confederations Cup triumph will feature also.
Manchester United finished sixth past year but will be playing in the Champions League after beating Ajax 2-0 in the Europa League final in May - a reward Wenger has never been keen on. With a transfer season of no significant signings, Spurs must rely heavily on Kane to stay fit and fire again if they are to entertain any title hopes.
Wenger proved last season, particularly in the 2-1 victory over Antonio Conte's side in the FA Cup final in May, that he is still a master tactician. "Look, I left them all out because some are short of preparation, like Alexis Sanchez", Wenger said.
"Now there is another game". The problem for Arsenal in recent times has been the lack of a leader on the field when things start to go wrong and the atmosphere becomes too static for the team.
The Gunners seem to be heading towards an inevitable conclusion, as players are reportedly convinced that the star wants to leave the club. Yes it has only been a few months since the season ended, but on Sunday the Premier League 2017-2018 season will officially kick off.
"I think he will be here for this season and if we manage to do it for more seasons, we'll do it as well. It's an important game, for sure".