The song's overwhelming popularity has inspired a number of remixes and parodies (this one is a particular treat), and while both artists have generally welcomed alternative versions of their song, they've recently taken a stand against one in particular: the one done by the Venezuelan government.
Despacito, the mega-hit by Luis Fonsi and Daddy Yankee - as well as a partial English version with Justin Bieber - has been far and away the song of the summer with all-day radio play and its recent record-breaking turn as the most-streamed song of all-time with 4.6 billion plays in three months since its April release.
According to reports, President Maduro has appropriated the song for a controversial new citizen's assembly, which will be elected on Sunday to rewrite the constitution.
The 39-year-old musician said he was not consulted by Maduro and that he had not given his permission for the song's use. "The constituent assembly moves forward". Luis Fonsi was the first to respond, saying he did not authorize or was asked for the use or the change of the lyrics of his song.
"My music is for all those who want to listen to it and enjoy it, not to be used as propaganda that tries to manipulate the will of a people who are crying out for their freedom", he added on the social media site.
Daddy Yankee posted a picture of Mr Maduro with a large red cross over it on Instagram. "You dictatorial regime is a mockery, not only for my Venezuelan brothers, but also for the whole world".
"What do you think?" he said, more an exclamation than a question.
More than 7.5 million Venezuelans recently voted in a symbolic referendum against the constituent assembly and the opposition has vowed to hold a 48-hour strike in protest this week.
Maduro and his leftwing government have been strongly criticised by several big Latin American nations, including Mexico, Brazil and Argentina, for pushing on with the plan to change Venezuela's constitution.