Jon Watts' film gathered $117 million in domestic sales, for a grand total of $257 million when oversea box office numbers are added in. What Maguire and director Sam Raimi also did-when Spider-Man came out in 2002-was kick-start what would become the superhero movie revolution we have witnessed in the decade since.
But the solid showing by "Spider-Man: Homecoming" has helped to quiet talk - at least for now - that sequels and reboots have had their day.
But "Homecoming" returned to "Spider-Man" teenage roots, casting Tom Holland in the part.
Despicable Me 3 opened in China, where it collected over $20 million to add to its growing sum.
Of all the superheroes to receive the big-screen treatment, Spider-Man is right up there with Batman when it comes to the number of movies-and unrelated movie continuities-he has been portrayed in.
As for the character, "Homecoming" shows that even though Holland is the third Spider-Man in 15 years, audiences will still line up for the hero's adventures.
Homecoming takes place after the events of Civil War, and 15-year-old Peter Parker feels neglected by Iron Man, struggling to adjust back to the mundaneness of high school while disguising his superpowers.
"This original 22-movie arc ends with the untitled "Avengers" in May of 2019 and then two months later it will be Peter and Spider-Man (on July 5, 2019) that usher us into the aftermath and how things proceed from there".
The result is Spider-Man: Homecoming, which is merrily racking up moolah at the box office right now. That makes the film one of the best-reviewed superhero movies of all time.